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Cardarine (GW-501516) Review: My Results, Dosage, & More!


cardarine gw501516 guide

My name is Jon Anthony, and I’ve personally tried Cardarine for fat loss and body building—and in this article, I’m going to relay my experience.

Not only that, but I’ll also cover the results I got from my Cardarine cycle, the dosage I used, which SARMs to stack it with, and much more.

If you want an honest Cardarine (GW-501516) review, then take it from me, that this supplement is GREAT for endurance and fat loss.

So, with that in mind, let’s take a look at this interesting new supplement, how to use it safely, what the evidence suggests, and much, much more.

What is Cardarine?

First off, it’s very important to understand that Cardarine, sometimes referred to by its research name GW-501516, is not technically a SARM.

Technically, Cardarine is a PPAR delta receptor agonist, but it’s grouped together with SARMs, because they’re all sold as research chemicals.

Cardarine was initially developed as a drug to treat people suffering from metabolic and cardiovascular diseases, but isn’t FDA approved.

Of course, this hasn’t stopped body builders from using Cardarine (along with other SARMs) to rapidly shred fat and build muscle, though.

How Does Cardarine Work?

Similar to other SARMs like RAD 140 or Ligandrol, Cardarine is very fast acting and begins exerting effects on the body shortly after ingestion.

It works by binding to peroxisome proliferator-activated delta receptors in the body, and switches the liver’s energy source to fatty acids. [R]

Normally, your liver uses glucose for energy, but by switching this source to fatty acids, Cardarine effectively puts you in a state of ketosis.

Buy USA Made Cardarine Here!

This is why researchers believed Cardarine could be used as a drug to treat those suffering from cardiovascular disease and type II diabetes. [R]

It didn’t take long for body builders to notice that Cardarine could ALSO be used to increase metabolic rate and rapidly shred fat, however…

Cardarine (GW501516) Benefits

GW 501516 Cardarine Benefits

The biggest benefits of Cardarine, or GW501516, are drastically enhanced endurance, and rapid fat loss—this is why most people end up taking it.

That being said, there’s also a ton of other research-backed health benefits of using Cardarine, such as lowered cholesterol, and much more.

Overview of Benefits

  • Supercharged Endurance
  • Accelerated Fat Burning
  • Lower Cholesterol Levels
  • Reduced Oxidative Stress
  • Better Cardiovascular Health

Cardarine has a ton of research-backed benefits, and is great to stack with other SARMs for a lean bulk, or to accelerate fat loss while cutting.

It’s also great to pair with other SARMs, because the HDL cholesterol increasing effects of Cardarine can offset the HDL decreasing side effects of some SARMs.

Supercharged Endurance

Perhaps the biggest benefit of taking Cardarine, or GW501516, is its potential to supercharge both muscle and cardiovascular endurance.

One of the most famous studies regarding Cardarine found that it improved endurance by 216% when compared to placebo. [R]

Buy USA Made Cardarine Here!

I personally noticed this on my cycle, too. I’ve taken a lot of nutrition supplements in my life, and NOTHING worked as well as Cardarine.

Enhanced Fat Loss

Another great benefit of Cardarine is that it RAPIDLY accelerates fat loss—hell, when I was on my cycle I felt the pounds just melting away.

In fact, some users report losing up to 25 pounds of bodyfat from just one cycle of Cardarine, even if their nutrition isn’t that great.

I didn’t personally notice this much fat loss on Cardarine, but to be fair, I was already around 12% bodyfat, so losing 7 pounds of fat is pretty good.

Cardarine Results

Ostarine Cardarine LGD 4033 Before After Results

The above picture is from a 90 day SARMs cycle I did two years ago, consisting of Ostarine, Ligandrol, and of course, Cardarine (GW501516).

I first documented my Cardarine results in my SARMs before and after article, but I’ll give you a quick recap about my experience here.

Overview of My Results

  • Ostarine Dosage: 25 mg
  • Ligandrol Dosage: 10 mg
  • Cardarine Dosage: 10 mg
  • Cycle Length: 90 Days
  • Muscle Gain: 18 Pounds
  • Fat Loss: 7 Pounds

Every day, for 90 days, I took my doses first thing in the morning on an empty stomach. I took my doses on both workout days and rest days.

These days, I get my SARMs from Chemyo, which I wrote a full review on. They’re one of the best SARMs vendors out there, due to their high quality, competitive prices, and extremely rigorous 3rd party testing.

Cardarine Dose & Stacks

For my first SARMs cycle, I took 10 mg of Cardarine, which I stacked with Ostarine and Ligandrol. I had great results, and would do it again.

Clinical studies done on humans have studied the effects of Cardarine doses ranging from 2.5 mg to 10 mg, but nothing more than this, though.

Dosing Guidelines

  • Beginner: 5 mg per day
  • Intermediate: 10 mg per day
  • Advanced: 20 mg per day

That being said, many body builders report using up to 20 mg per day of Cardarine, and having no adverse short term health side effects.

For an advanced dosage, that would be equivalent to taking one full dropper of the GW501516 from Chemyo, each day.

How to Take It

Once you buy some Cardarine (ideally from a source I recommend), you can get started by taking one full dropper per day, even on rest days.

The reason why you take Cardarine (and other SARMs) on rest days, is to maintain an even level of these supplements in your blood stream.

Buy USA Made Cardarine Here!

Some people take multiple Cardarine doses each day, but this isn’t necessary to maintain stable blood levels, due to Cardarine’s half life.

Stack Guidelines

If you want to build even more muscle and burn even more fat, then you may want to consider combining GW501516 with other SARMs.

I explain all of this in my SARMs stack guide, so I recommend you start by reading that article, because it has everything you need to know.

Cutting StackBulking Stack
Cardarine – 20 mg per dayCardarine – 10 mg per day
RAD 140 – 15 mg per dayLigandrol – 20mg per day
Ostarine – 25 mg per dayMK 677 – 50 mg per day

You could get awesome results by just taking those exact dosages each day for either an 8 week cycle, or a 12 week cycle, followed by a PCT.

In general, Cardarine works best for cutting and fat loss, so people typically either use it on a cutting cycle, or to do a really lean bulk.

Side Effects & Safety

Most body builders who use Cardarine for fat loss experience no short term side effects—I didn’t experience any myself, either.

Some people claim that Cardarine may accelerate cancer growth, but in my opinion, the research to back this claim is extremely sketchy at best.

The study in question, which is often cited to state that Cardarine causes cancer, gave lab rats a ridiculous amount of this drug for WAY too long.

Does Cardarine Cause Cancer?

In this study, researchers gave Han Wistar lab rats a Cardarine dosage of 3 mg per kg per day, for approximately 104 weeks, or 2/3 of their life. [R]

If we do the math, this would be equivalent to giving humans over 200 mg of Cardarine PER DAY, for 2/3 of their lives, or 50 fucking years.

To say that “Cardarine causes cancer” because of this study would be like saying that “coffee is will kill you” because someone drank 5,000 cups in 24 hours and died of a heart attack. No shit!

Is Post Cycle Therapy Required?

Thankfully, because Cardarine is not a SARM, it will NOT shut down your natural testosterone production even slightly, so no PCT is needed.

Cardarine is a PPAR delta receptor agonist, which means that it won’t lower testosterone levels, or have any other hormonal side effects.

If you use Cardarine with other SARMs for a stack however, it may be a good idea to do one. Read my SARMs PCT guide for how to do this.

The Bottom Line

GW 501516 Cardarine Benefits

In summary, Cardarine is one of the best research supplements out there for burning fat, enhancing endurance, and helping you get shredded.

If you do decide to buy Cardarine, be sure to get it from a good source that tests every batch of their SARMs for purity, so you know they’re legit.

Personally I recommend Chemyo, which has tons of different SARMs for sale. A full 60 day cycle of their Cardarine is less than $100.

They also gave me a discount code to give you, too—if you use the code “MD10” you’ll save 10% off on any SARMs you choose to purchase.

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2 years ago

Hey Jon, my rat just started a cycle of LGD-4033 and GW-0742 like two days ago. The GW-0742 is supposedly nicknamed “Carderine 2.0” or even “Super Carderine” and is purported to be a little better with regards to fat loss and about even with regards to endurance building. You should do a review on it.

9 months ago
Reply to  LeftyBillC


2 years ago

Hey man, I need to find my path again. What’s your email? I need talk with u

3 years ago

Hi Jon
You said that GW will put you into ketosis. Did you ever experienced the keto flu while you were on GW. How was your carb intake while you were on it?

3 years ago

Is the blog on hiatus or even dead?

3 years ago

Hey Jon! I’m literally so glad I came across your blog lmao, I’m a (just turned sixteen year old) girl and I was just looking up “how to get laid in high school” because I’m horny af. I saw that this content is mainly for guys but it really gave me insight and its so true how girls prefer dominant guys myself included. I love how you don’t sugarcoat things. All your articles are so fucking funny and I’ll be sure to keep up with the posts man. I can see how you laid so many girls and its hella interesting seeing your posts like “How I banged 17 girls in 5 weeks” it made me burst out laughing. XD Thanks for this blog!

3 years ago

Hey there! Thanks for this! I just purchased Cardarine from Proven Peptides! To clarify, one full dropper is 10mg? Correct? (I realize it is 10mg/ml….but I want to make sure a full dropper is 1 full ml) And is one full dropper a dropper completely filled from end to end, or does it only fill about halfway? I want to make 100% sure I get 10mg…and not more. Thanks so much in advance

3 years ago

Hey Jon,

Keep killing it with your blog man.

I’m keeping an eye out for that blog ebook of yours.

I saw you’re working on it from your homepage.

My girlfriend wants to tone up her glutes so that she can have an ass that looks fantastic in a bikini.

What sort of exercises and diet should she go on to make that happen.

3 years ago
Reply to  Jon Anthony

Hi Jon, a part of fat loss that I struggle with the most is the appetite suppression. I can usually cut for about 3-4 weeks at most but then the hunger cravings get way too intense and I also start to feel light-headed/dizzy throughout the day the longer I cut. So how are you able to maintain your appetite suppression long enough to cut the fat to gets abs? Don’t you ever get cravings? Thanks

3 years ago
Reply to  Jon Anthony

Haha thanks for the reply, though unfortunately i’ve already experimented with those and didn’t help at all. Oh well, I guess everyone’s body is just different

3 years ago
Reply to  Jon Anthony

My man.

Thank you.

Jon Simmons
2 years ago
Reply to  Brendan

Try improving your diet and fitness and improve weight lifting. I did this and it worked for me.


What's Up, I'm Jon Anthony

Women. Fitness. Money. I’ll help you achieve it.

After dropping out of college to pursue my dreams, I started this blog as a way to help other men do the same.

What started off as a fun hobby, grew into a full-scale 6-figure business that’s changing the lives of men worldwide.


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